Linear regression analysis of mean value of ADC with and without CSF removal, showing the effects of different scanner versions.

<p>Linear regression analysis of mean value of ADC with and without CSF removal, showing the effects of different scanner versions.</p

Intra-class correlation coefficient between ADC and MD histogram parameters (n denotes the number of scans).

<p>Values of 0.833* and of 0.719** after removal of two outliers.</p

Effects of clinical scores, age and sex (represented by their regression coefficients) compared to the random scanner effect (represented by its standard deviation) on different ADC histogram parameters.

<p>Note that no test was performed for random effects.</p

Bland–Altman plots for the mean value of ADC vs MD histograms after CSF removal on GE scanners with upgrade Signa 11 new and Signa 12+.

<p>Bland–Altman plots for the mean value of ADC vs MD histograms after CSF removal on GE scanners with upgrade Signa 11 new and Signa 12+.</p

Intra-class correlation between ADC histogram parameters obtained with and without different image corrections (n denotes the number of scans) (only baseline scans were used in these analyses).

<p>All p-values are less than 0.0001</p

Linear regression analysis of mean value derived from ADC histograms vs mean MD values obtained with DTI after CSF removal (x 10⁻⁴ mm²/s) on the GE scanner.

<p>The graph shows the large effects of different scanner versions (software and hardware updates). If the ADC and MD measures appear well correlated overall, the graph illustrates that they clearly depend on the scanner version and are not concordant since all regression lines significantly differ from the perfect concordance line (dashed line).</p

Bland–Altman plots for parameters derived from ADC histograms with and without application of different image corrections.

<p>Bland–Altman plots for parameters derived from ADC histograms with and without application of different image corrections.</p

Correlation coefficients between ADC and MD histogram parameters (n denotes the number of scans); all p-values are less than 0.0001

<p>Values of 0.935* and 0.779** after removal of two outliers.</p